Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression.

@article{Palmer2014IntegrinfreeTC,
  title={Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression.},
  author={Trenis D. Palmer and Carlos H. Mart{\'i}nez and Catalina V{\'a}squez and Katie E. Hebron and Celestial R. Jones-Paris and Shanna A. Arnold and Susanne M. Chan and Venu Chalasani and Jose A. Gomez-Lemus and Andrew J. K. Williams and Joseph L. Chin and Giovanna A Giannico and Tatiana Ketova and John D Lewis and Andries Zijlstra},
  journal={Cancer research},
  year={2014},
  volume={74 1},
  pages={
          173-87
        }
}
Normal physiology relies on the organization of transmembrane proteins by molecular scaffolds, such as tetraspanins. Oncogenesis frequently involves changes in their organization or expression. The tetraspanin CD151 is thought to contribute to cancer progression through direct interaction with the laminin-binding integrins α3β1 and α6β1. However, this interaction cannot explain the ability of CD151 to control migration in the absence of these integrins or on non-laminin substrates. We… CONTINUE READING

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