Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts.

@article{Sarkissian1999IntegrinER,
  title={Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts.},
  author={Margaret Sarkissian and Robert Lafyatis},
  journal={Journal of immunology},
  year={1999},
  volume={162 3},
  pages={
          1772-9
        }
}
Growth of and metalloproteinase production by fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) contribute to cartilage and bone destruction associated with development of the expanding inflammatory tissue referred to as pannus. Increased levels of extracellular matrix (ECM) proteins in the pannus suggest that intracellular signals generated through integrin receptors might control these processes. We developed a cell culture system permitting accurate assessment of… CONTINUE READING

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