Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.

@article{Zhou2005IntegrinED,
  title={Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.},
  author={H. Mimi Zhou and Randall H. Kramer},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 11},
  pages={10624-35}
}
Integrin-ligand binding regulates tumor cell motility and invasion. Cell migration also involves the Rho GTPases that control the interplay between adhesion receptors and the cytoskeleton. We evaluated how specific extracellular matrix ligands modulate Rho GTPases and control motility of human squamous cell carcinoma cells. On laminin-5 substrates, the epithelial cells rapidly spread and migrated, but on type I collagen the cells spread slowly and showed reduced motility. We found that RhoA… CONTINUE READING