Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

@article{Capodici1998IntegrindependentHA,
  title={Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.},
  author={Constance Capodici and Michael H. Pillinger and Gangwen Han and Mark R Philips and Gerald Weissmann},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 1},
  pages={165-75}
}
AA stimulates integrin-dependent neutrophil adhesion, a critical early step in acute inflammation. However, neither the signaling pathway(s) of AA-stimulated adhesion, nor whether AA acts directly or through the generation of active metabolites, has been elucidated. Previously, we have observed a tight association between neutrophil Erk activation and homotypic adhesion in response to chemoattractants acting through G protein-linked receptors. We now report a similar association between… CONTINUE READING