Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.

Abstract

Focal adhesions are mechanosensitive elements that enable mechanical communication between cells and the extracellular matrix. Here, we demonstrate a major mechanosensitive pathway in which α-actinin triggers adhesion maturation by linking integrins to actin in nascent adhesions. We show that depletion of the focal adhesion protein α-actinin enhances force… (More)
DOI: 10.1073/pnas.1220723110

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