Integrin-dependent Control of Translation: Engagement of Integrin αIIbβ3 Regulates Synthesis of Proteins in Activated Human Platelets

@article{Pabla1999IntegrindependentCO,
  title={Integrin-dependent Control of Translation: Engagement of Integrin $\alpha$IIb$\beta$3 Regulates Synthesis of Proteins in Activated Human Platelets},
  author={R. Pabla and A. Weyrich and D. Dixon and P. Bray and T. McIntyre and S. Prescott and G. Zimmerman},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={175 - 184}
}
Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell–cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using… Expand
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