Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion.

@article{Kappert2009IntegrinCF,
  title={Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion.},
  author={Kai Kappert and Heike Meyborg and Bernadette Baumann and Vesna Furundzija and Jan Kaufmann and Kristof Graf and Dietger Stibenz and Eckart Fleck and Philipp Stawowy},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 7},
  pages={1511-7}
}
Vascular smooth muscle cell (VSMC) invasion is a key element in atherogenesis and restenosis, requiring integrins for adhesion/de-adhesion as well as matrix metalloproteinases (MMPs) for focalized proteolysis. Among the MMP family, pro-MMP-2 is unique in its activation, depending on the formation of a multiprotein complex with MT1-MMP/TIMP-2 at the cell… CONTINUE READING