Integrin avidity regulation: are changes in affinity and conformation underemphasized?

@article{Carman2003IntegrinAR,
  title={Integrin avidity regulation: are changes in affinity and conformation underemphasized?},
  author={Christopher V. Carman and Timothy A Springer},
  journal={Current opinion in cell biology},
  year={2003},
  volume={15 5},
  pages={547-56}
}
Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation. 

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