Integrin-associated proteins as potential therapeutic targets.


SUMMARY Integrins are adhesion receptors important for hematopoiesis, leukocyte trafficking, and formation of immunological synapses; hence, they may provide targets for therapeutic intervention in leukocyte-driven pathologies. Blocking integrin-ligand binding is one strategy for inhibiting integrins; however, a complete loss of integrin function can lead… (More)
DOI: 10.1111/j.1600-065X.2008.00640.x

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