Integrin-associated protein is an adhesion receptor on sickle red blood cells for immobilized thrombospondin.

@article{Brittain2001IntegrinassociatedPI,
  title={Integrin-associated protein is an adhesion receptor on sickle red blood cells for immobilized thrombospondin.},
  author={Julia E Brittain and K J Mlinar and Craig Anderson and Eugene P. Orringer and Leslie V Parise},
  journal={Blood},
  year={2001},
  volume={97 7},
  pages={2159-64}
}
The adhesive protein thrombospondin (TSP) potentially mediates sickle (SS) red blood cell (RBC) adhesion to the blood vessel wall, thereby contributing to vaso-occlusive crises in sickle cell disease. We previously reported that SS RBCs bind to immobilized TSP under flow conditions, whereas normal (AA) red cells do not. However, the SS RBC receptors that mediate this interaction are largely unknown. Here it is reported that integrin-associated protein (IAP), or CD47, mediates the adhesion of… CONTINUE READING