Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.

@article{Kitchens2012IntegrinAP,
  title={Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.},
  author={William H. Kitchens and Divya Haridas and Maylene E. Wagener and Mingqing Song and Allan D. Kirk and Christian P Larsen and Mandy L Ford},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 1},
  pages={69-80}
}
The success of belatacept in late-stage clinical trials inaugurates the arrival of a new class of immunosuppressants based on costimulatory blockade, an immunosuppression strategy that disrupts essential signals required for alloreactive T-cell activation. Despite having improved renal function, kidney transplant recipients treated with belatacept experienced increased rates of acute rejection. This finding has renewed focus on costimulatory blockade-resistant rejection and specifically the… CONTINUE READING
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