Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity

@article{Huttenlocher1998IntegrinAC,
  title={Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity },
  author={Anna Huttenlocher and Margot Lakonishok and Melissa Kinder and Stanley Wu and Tho Q. Truong and Karen A. Knudsen and Alan F. Horwitz},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={515 - 526}
}
Integrin receptors play a central role in cell migration through their roles as adhesive receptors for both other cells and extracellular matrix components. In this study, we demonstrate that integrin and cadherin receptors coordinately regulate contact-mediated inhibition of cell migration. In addition to promoting proliferation (Sastry, S., M. Lakonishok, D. Thomas, J. Muschler, and A. Horwitz. 1996. J. Cell Biol. 133:169-184), ectopic expression of the alpha5 integrin in cultures of primary… CONTINUE READING

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