Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription.

@article{Loessner2009IntegrinAU,
  title={Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription.},
  author={Daniela Loessner and Claudia Abou-Ajram and Anke Benge and Marc Aumercier and Manfred Schmitt and Ute Reuning},
  journal={Journal of cellular physiology},
  year={2009},
  volume={220 2},
  pages={367-75}
}
We previously showed that integrin alphavbeta3 overexpression and engagement by its ligand vitronectin increased adhesion, motility, and proliferation of human ovarian cancer cells. In search of differentially regulated genes involved in these tumor biological events, we previously identified the integrin-linked kinase (ILK) to be under control of alphavbeta3. In the present investigation we demonstrated significantly upregulated ILK protein as a function of alphavbeta3 in two ovarian cancer… CONTINUE READING

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