Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.

@article{Gupta2009IntegrinAM,
  title={Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.},
  author={Shiv Kumar Gupta and Nicholas E. Vlahakis},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 12},
  pages={2043-54}
}
Integrins are important mediators of cell adhesion and migration, which in turn are essential for diverse biological functions, including wound healing and cancer metastasis. The integrin alpha9beta1 is expressed on numerous mammalian tissues and can mediate accelerated cell migration. As the molecular signaling mechanisms that transduce this effect are poorly defined, we investigated the pathways by which activated integrin alpha9beta1 signals migration. We found for the first time that… CONTINUE READING

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