Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.

@article{Mller1997IntegrinAI,
  title={Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.},
  author={Ulrich F M{\"u}ller and Demin Wang and Sumiko Denda and Juanito J. Meneses and Roger A. Pedersen and Louis French Reichardt},
  journal={Cell},
  year={1997},
  volume={88 5},
  pages={603-13}
}
We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithelium and metanephric mesenchyme are essential for kidney morphogenesis. In alpha8 mutant homozygotes, growth and branching of the ureteric bud and recruitment of mesenchymal cells… CONTINUE READING