Integrin alpha6beta1 plays a significant role in the attachment of hepatoma cells to laminin.

@article{Torimura1999IntegrinAP,
  title={Integrin alpha6beta1 plays a significant role in the attachment of hepatoma cells to laminin.},
  author={Takuji Torimura and Takato Ueno and Motoaki Kin and Rika Ogata and Shu Inuzuka and Hisanori Sugawara and R Kurotatsu and Mitsuo Shimada and Hirohisa Yano and Masamichi Kojiro and Kyuichi Tanikawa and Michio Sata},
  journal={Journal of hepatology},
  year={1999},
  volume={31 4},
  pages={734-40}
}
BACKGROUND/AIMS Tumor invasion and metastasis consist of a series of complex events. During this process, the ability of tumor cells to adhere to laminin, a major component of basement membranes, is required at various steps. The expression of laminin-binding integrins and the extent of tumor metastasis and progression appear to be related. In hepatocellular carcinoma, increased expression of laminin-binding integrins is observed. However, little is known concerning the possible functional… CONTINUE READING
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