Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin.

@article{Alfandari2003IntegrinAS,
  title={Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin.},
  author={Dominique Alfandari and H{\'e}l{\`e}ne Cousin and Alban Gaultier and Benjamin G. Hoffstrom and Douglas W. DeSimone},
  journal={Developmental biology},
  year={2003},
  volume={260 2},
  pages={449-64}
}
During early embryonic development, cranial neural crest cells emerge from the developing mid- and hindbrain. While numerous studies have focused on integrin involvement in trunk neural crest cell migration, comparatively little is known about mechanisms of cranial neural crest cell migration. We show that fibronectin, but not laminin, vitronectin, or type I collagen can support cranial neural crest cell migration and segmentation in vitro. These behaviors require both the RGD and "synergy… CONTINUE READING

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