Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway.

Abstract

We have previously shown that prothrombin, a blood coagulation factor, can cause an inhibition of DNA synthesis in normal rat hepatocytes. To explore the mechanisms of this prothrombin action, we examined its effects on the activation of fibronectin receptor integrin alpha5, since fibronectin was found to be degraded by prothrombin actions in primary… (More)
DOI: 10.1002/jcp.21429

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Cite this paper

@article{Wang2008IntegrinAE, title={Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway.}, author={Ziqiu Wang and Meifang Wang and Brian I Carr}, journal={Journal of cellular physiology}, year={2008}, volume={216 2}, pages={551-7} }