Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice.

@article{Lundberg2006IntegrinAR,
  title={Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice.},
  author={Sofie Lundberg and Johan Lindholm and Lennart Lindbom and Per M Hellstr{\"o}m and Joachim Werr},
  journal={Inflammatory bowel diseases},
  year={2006},
  volume={12 3},
  pages={
          172-7
        }
}
BACKGROUND Human inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis), is associated with leukocyte accumulation in the inflamed intestinal tissue. Recent studies strongly suggest a role of beta1 integrin receptors in regulating tissue damage and disease symptoms related to inflammatory bowel disease. The aim of this study was to investigate the role of the collagen-binding alpha2beta1 integrin (CD49b/CD29) in dextran sodium sulfate-induced colitis in mice. METHODS… CONTINUE READING

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