Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1

@article{Blystone1994IntegrinAV,
  title={Integrin alpha v beta 3 differentially regulates adhesive and
 phagocytic functions of the fibronectin receptor alpha 5 beta 1},
  author={Scott D Blystone and Irene L. Graham and F P Lindberg and Eric J. Brown},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={1129 - 1137}
}
The plasma protein fibronectin is an important opsonin in wound repair and host defense. To better understand the process of fibronectin-mediated phagocytosis, we have transfected K562 cells, which endogenously express alpha 5 beta 1, with alpha v beta 3. In these transfectants, antibodies to alpha v beta 3 block phagocytosis of fibronectin-opsonized beads completely, even though half the ingestion occurs through endogenous alpha 5 beta 1 receptors. alpha 5 beta 1-mediated adhesion to… CONTINUE READING
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