Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen.

@article{Bradshaw1995IntegrinA2,
  title={Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen.},
  author={Amy Dodd Bradshaw and Kelly M McNagny and Dennis B. Gervin and Gordon M. Cann and Thomas Graf and Dennis O Clegg},
  journal={Development},
  year={1995},
  volume={121 11},
  pages={3593-602}
}
In the developing nervous system, the extracellular matrix provides a source of extrinsic cues to guide determination of cell fate, neuroblast migration, axon outgrowth and synapse formation. In the neural retina, undifferentiated neuroepithelial precursor cells contact extracellular matrix that contains multiple collagen types. Collagens have been shown to support retinal cell adhesion and neurite outgrowth, but the integrin receptors mediating neuronal responses are not understood. Here we… CONTINUE READING

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