Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.

@article{Petitclerc1999IntegrinAP,
  title={Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.},
  author={{\'E}ric Petitclerc and Staffan Str{\"o}mblad and T L von Schalscha and Francesc Mitjans and Jaime Piulats and Anthony M. P. Montgomery and David A. Cheresh and P. C. Brooks},
  journal={Cancer research},
  year={1999},
  volume={59 11},
  pages={2724-30}
}
Growth and dissemination of malignant melanoma has a profound impact on our population, and little is known concerning the mechanisms controlling this disease in humans. Evidence is provided that integrin alpha(v)beta3 plays a critical role in M21 melanoma tumor survival within human skin by a mechanism independent of its known role in angiogenesis. Antagonists of alpha(v)beta3 blocked melanoma growth by inducing tumor apoptosis. Moreover, M21 melanoma cell interactions with denatured collagen… CONTINUE READING

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