Integrin Trafficking and the Control of Cell Migration

@article{Caswell2006IntegrinTA,
  title={Integrin Trafficking and the Control of Cell Migration},
  author={Patrick T. Caswell and Jim C. Norman},
  journal={Traffic},
  year={2006},
  volume={7}
}
In the late 1980s and early 1990s, the observation that certain integrin heterodimers are continually internalized from the plasma membrane into endosomal compartments and subsequently recycled back to the cell surface indicated that the endocytic and recycling pathways have the potential to exert minute‐to‐minute control over integrin function. This insight has prompted others to study the regulation of integrin trafficking in more detail. This review aims to summarize the findings of studies… 

Endocytic Trafficking of Integrins in Cell Migration

Integrin traffic

Mechanistic insight is provided into how integrin traffic is regulated in cells by controlling small GTPases or stabilizing cytoskeletal tracks that are crucial for efficient traffic of integrins to the plasma membrane.

Integrins: masters and slaves of endocytic transport

New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration and can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.

Quantitative Analysis of Integrin Trafficking.

This chapter will focus on quantitative approaches based on cell surface biotinylation and capture ELISA to measure endocytosis, recycling, and cell surface levels of integrin receptors.

Trafficking and Cell Migration

Taken together, endocytosis enables migrating cells and tissues to dynamically modulate their adhesion and signalling, allowing them to efficiently migrate through their extracellular environment.

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

It is demonstrated that β1 integrin (known as PAT-3 in Caenorhabditis elegans), but not β3, is transported from the plasma membrane to the trans-Golgi network, to be resecreted in a polarized manner.

Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion: cell matrix receptors are trafficked through the late endosomal pathway in a way that dictates how cells migrate.

  • E. RaineroJ. Norman
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2013
How the exchange of adhesion receptors and other key regulators of cell migration between late endosomes/lysosomes and the plasma membrane can promote dynamic turnover of adhesions during cell migration is discussed.

Distinct Recycling of Active and Inactive β1 Integrins

The endocytic trafficking of active and inactive β1 integrins in cancer cells is investigated and the possibility of a previously unappreciated crosstalk between pathways regulating integrin activity and traffic is implied.

Endocytosis and spatial restriction of cell signaling

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