Corpus ID: 16807979

Integrin Targeted Delivery of Chemotherapeutics

@article{Chen2011IntegrinTD,
  title={Integrin Targeted Delivery of Chemotherapeutics},
  author={Kai Chen and Xiaoyuan Chen},
  journal={Theranostics},
  year={2011},
  volume={1},
  pages={189 - 200}
}
Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological activity to the site or tissue of action. Integrins are a family of heterodimeric transmembrane glycoproteins involved in a wide range of cell-to-extracellular matrix (ECM) and cell-to-cell interactions. As cell surface receptors, integrins readily interact with extracellular ligands and play a vital role in… Expand
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