Integrin Function in Breast Carcinoma Progression

  title={Integrin Function in Breast Carcinoma Progression},
  author={Leslie M. Shaw},
  journal={Journal of Mammary Gland Biology and Neoplasia},
The differentiation and function of mammaryepithelial cells is dependent upon the combined actionof growth factor/hormone receptors and integrinreceptors, which act in concert to control the signals required for normal cell function. It is nowbecoming clear that integrin receptors also contributeto carcinoma cell behavior and that alterations inexpression and function during transformation have a large impact on breast carcinoma progression.The focus of this review is to discussintegrin… CONTINUE READING
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Downstream events in mammary gland morphogenesis mediated by reextumorassociated antigen TSP180 . Identity with a 6 b 4 in the integrin superfamily

  • S. A. Santoro, M. M. Zutter
  • J . Biol . Chem . Cancer Res .
  • 1998

Extracellular matrix breast carcinoma is correlated with reduced survival

  • N. Boudreau, M. J. Bissell
  • Cancer Res
  • 1998

Integrins take partners :

  • N. Hogg
  • Science
  • 1998
1 Excerpt

Matrix - kinase B / Akt cellular survival pathway

  • A. J. Wagner, S. D. Conzen
  • EMBO J . dependent Tiam 1 / Rac signaling in…
  • 1998

Prognostic value of a 6 b 4 integrin

  • naghi, S. Menard
  • 1998

Reciprocal p 53 reduces growth and metastases of a malignant human breast interactions between b 1integrin and epidermal growth factor cancer in nude mice

  • M. J. Bissell
  • Human Gene Therapy Proc . Natl . Acad . Sci . U…
  • 1998
2 Excerpts

tion both activate a phosphoinositide 3-OH kinase and protein

  • E. E. Sander, S. van Delft, J. P. ten Klooster, R.A.T. Reid
  • 1998

Activation of phosphoinositide 3-Oh 66

  • A. M. Mercurio
  • 1997
3 Excerpts

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