Integrin-Dependent Signal Cascades in Chondrocyte Mechanotransduction

@article{MillwardSadler2004IntegrinDependentSC,
  title={Integrin-Dependent Signal Cascades in Chondrocyte Mechanotransduction},
  author={Sarah J. Millward-Sadler and Donald Salter},
  journal={Annals of Biomedical Engineering},
  year={2004},
  volume={32},
  pages={435-446}
}
Mechanical forces influence chondrocyte metabolism and are critically important for maintenance of normal cartilage structure and integrity. In cells of the musculoskeletal system and mechanoresponsive cells in other tissues, integrins seem to be involved in the mechanotransduction process. Integrin activity is important in the early cellular responses to mechanical stimulation, regulating activation of a number of intracellular cascades that induce changes in gene expression and tissue… 
Integrin signaling in skeletal development and function.
TLDR
The role of integrins in skeletogenesis and their influence on the physiology and pathophysiology of cartilage, bone, and tendon are discussed.
Signaling networks and transcription factors regulating mechanotransduction in bone
TLDR
The major signaling cascades and transcription factors that control bone and cartilage mechanobiology are considered and the influence of the mechanical microenvironment on the determination of skeletal morphology is discussed.
Mechanical regulation of signaling pathways in bone.
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An understanding of mechanical regulation of bone signaling is crucial to understanding bone physiology, the etiology of diseases such as osteoporosis, and to the development of interventions to improve bone strength.
Integrin-Mediated Interactions in Cartilage Physiology and Pathophysiology
The development and homeostasis of cartilaginous tissues are regulated by diverse microenvironmental cues including integrin-mediated interactions between chondrocytes and the extracellular matrix
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TLDR
The data suggest that integrins may initiate the cellular response of osteocytes to dynamic fluid flow and may serve as mechanosensitive molecules in bone.
Crosstalk between integrin and G protein pathways involved in mechanotransduction in mandibular condylar chondrocytes under pressure.
TLDR
Increased integrin alpha5beta1 expression, enhanced stress fiber assembly, elevated G protein and vinculin level and up-regulated IP(3) channel sensitivity were found in the mechanotransduction process of MCCs under pressure.
Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes
Mechanotransduction is the mechanism through which living cells sense and respond to mechanical stimuli. In many tissues, including muscle, blood vessel, bone, ligament and cartilage,
Integrins, cadherins and channels in cartilage mechanotransduction: perspectives for future regeneration strategies
TLDR
This review focuses on the mechanotransduction properties of integrins, cadherins and ion channels in cartilaginous tissues to provide perspectives for cartilage regeneration.
Mechanical Determinants of Tissue Development
TLDR
The earliest-stage embryo, consisting of cells (embryonic stem cells (ESCs)) and thus lacking any defined extracellular matrix, is the earliest stage at which mechanical force balancing leads to cellular cues and pattern formation.
Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions
TLDR
The roles of several signaling molecules involved in adhesive signaling, such as integrin‐linked kinase (ILK) and Rho GTPases, during chondrocyte differentiation are beginning to be understood, and the actin cytoskeleton has been identified as a common target of these adhesive pathways.
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