Integrin β8 Signaling in Neonatal Hypoxic–Ischemic Brain Injury

  title={Integrin β8 Signaling in Neonatal Hypoxic–Ischemic Brain Injury},
  author={Li Zhang and Yi Qu and Binzhi Tang and Fengyan Zhao and Tao Xiong and D M Ferriero and Dezhi Mu},
  journal={Neurotoxicity Research},
Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen–glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic–ischemic (HI) brain injury is not known. Here, we report the function of β8 and signaling pathways involved in neuroprotection after neonatal brain HI. Neonatal HI model was performed in postnatal day 10 rats by ligating the right common carotid artery… CONTINUE READING
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