Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.

@article{Neri2011IntegrinR,
  title={Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.},
  author={Paola Neri and Li Ren and Abdel Kareem Azab and Matthew Brentnall and Kathy Gratton and Alexander C. Klimowicz and Charles A. Lin and Peter Duggan and Pierfrancesco Tassone and Adnan Mansoor and Douglas A Stewart and Lawrence H. Boise and Irene M Ghobrial and Nizar Jacques Bahlis},
  journal={Blood},
  year={2011},
  volume={117 23},
  pages={
          6202-13
        }
}
Integrin-β7 (ITGB7) mRNA is detected in multiple myeloma (MM) cells and its presence is correlated with MAF gene activation. Although the involvement of several integrin family members in MM-stoma cell interaction is well documented, the specific biologic functions regulated by integrin-β7 in MM are largely unknown. Clinically, we have correlated integrin-β7 expression in MM with poor survival outcomes post autologous stem cell transplantation and postsalvage therapy with bortezomib… CONTINUE READING
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