Integrin β1 is required for maintenance of vascular tone in postnatal mice

@article{Liu2012IntegrinI,
  title={Integrin β1 is required for maintenance of vascular tone in postnatal mice},
  author={Shangxi Liu and Andrew Leask},
  journal={Journal of Cell Communication and Signaling},
  year={2012},
  volume={6},
  pages={175-180}
}
Connective tissue is required for maintaining the integrity of tissues. Integrins are the cell surface receptors responsible for cell attachment to extracellular matrix; however, their tissue-specific role in this process is poorly understood. Here, we test whether integrin β1 is required for blood vessel maintenance and integrity in adult mice. We show that adult mice containing a fibroblast/smooth muscle cell-specific deletion of integrin β1 exhibit impaired bleeding time and maintenance of… CONTINUE READING