Integrin β1 is necessary for the maintenance of corneal structural integrity.

@article{Parapuram2011IntegrinI,
  title={Integrin β1 is necessary for the maintenance of corneal structural integrity.},
  author={Sunil K. Parapuram and Kun Huh and Shangxi Liu and Andrew Leask},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 11},
  pages={7799-806}
}
PURPOSE The precise role of a normal keratocyte in maintaining corneal structural integrity is unclear; it is generally considered to remain quiescent at the end of cell division. Given that integrins are essential for cell/extracellular matrix interactions, the authors tested the hypothesis that integrin expression by keratocytes is essential for corneal structure and function. METHODS Using a tamoxifen-dependent cre recombinase expressed under the control of a fibroblast-specific promoter… CONTINUE READING

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