Integrin β-3 is required for the attachment, retention and therapeutic benefits of human cardiospheres in myocardial infarction.

Abstract

Cardiovascular diseases remain the leading causes of death worldwide. Stem cell therapy offers a promising option to regenerate injured myocardium. Among the various types of stem cells, cardiosphere cells represent a mixture of intrinsic heart stem cells and supporting cells. The safety and efficacy of cardiosphere cells have been demonstrated in recent clinical trials. Cell-matrix interaction plays an important role in mediating the engraftment of injected stem cells. Here, we studied the role of integrin β-3 in cardiosphere-mediated cell therapy in a mouse model of myocardial infarction. Our results indicated that inhibiting integrin β-3 reduced attachment, retention and therapeutic benefits of human cardiospheres in mice with acute myocardial infarction. This suggests integrin β-3 plays an important role in cardiosphere-mediated heart regeneration.

DOI: 10.1111/jcmm.13325

Cite this paper

@article{Liu2017IntegrinI, title={Integrin β-3 is required for the attachment, retention and therapeutic benefits of human cardiospheres in myocardial infarction.}, author={Suyun Liu and Zhian Jiang and Li Qiao and Bingyan Guo and Wenliang Xiao and Xiaoguang Zhang and Liang Chang and Yongjun Li}, journal={Journal of cellular and molecular medicine}, year={2017} }