Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression

Abstract

Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin αvβ3 is associated with progression of a variety of human tumors. Here, we reveal a novel adhesion-independent role for integrin αvβ3 in pancreatic cancer and other carcinomas. Specifically, αvβ3 expressed in carcinoma cells enhanced… (More)

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Cite this paper

@inproceedings{Desgrosellier2009Integrin, title={Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression}, author={Jay S. Desgrosellier and Leo A. Barnes and David J. Shields and Miller Huang and Steven Kai Ming Lau and Nicolas Pr{\'e}vost and David Tarin and Sanford J Shattil and David A. Cheresh}, year={2009} }