Integrin αvβ3 binds a unique non-RGD site near the C-terminus of human tropoelastin

@article{Rodgers2004IntegrinB,
  title={Integrin αvβ3 binds a unique non-RGD site near the C-terminus of human tropoelastin},
  author={U. R. Rodgers and A. Weiss},
  journal={Biochimie},
  year={2004},
  volume={86},
  pages={173-178}
}
Tropoelastin is the soluble precursor of the essential resilient connective tissue protein elastin.We examined the binding of integrin avb3 to tropoelastin. In quantitative colorimetric solid-phase assays, purified avb3 demonstrated saturable, divalent cation-dependent, single-site binding behavior on tropoelastin with a dissociation constant of 3.8 ± 0.9 nM in the presence of 1 mM Mn 2+ which increased to 2 3±5n M in the presence of 1 mM Ca 2+ . Association with avb3 was localized to the C… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Protein Interaction Studies of MAGP-1 with Tropoelastin and Fibrillin-1*
  • 123
  • PDF
Hydrophobic Domains of Human Tropoelastin Interact in a Context-dependent Manner*
  • 71
  • PDF
Crystal Structure of the Extracellular Segment of Integrin αVβ3
  • 1,015
Domains in Tropoelastin That Mediate Elastin Depositionin Vitro and in Vivo *
  • 113
  • PDF
Microfibril-associated Glycoprotein-2 Specifically Interacts with a Range of Bovine and Human Cell Types via αVβ3 Integrin*
  • 64
  • PDF
Glycosaminoglycans Mediate the Coacervation of Human Tropoelastin through Dominant Charge Interactions Involving Lysine Side Chains*
  • 130
  • PDF
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1
2
3
4
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