Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

  title={Integrin-α9 is required for fibronectin matrix assembly
during lymphatic valve morphogenesis},
  author={Eleni Bazigou and Sherry Xie and Chun Hao Chen and Anne E. Weston and Naoyuki Miura and Lydia M Sorokin and Ralf H Adams and Andr{\'e}s F Muro and Dean Sheppard and Taija Makinen},
  booktitle={Developmental cell},
Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during embryogenesis, lymphatic valve leaflet formation is initiated by upregulation of integrin-alpha9 expression and deposition of its ligand fibronectin-EIIIA (FN-EIIIA) in the extracellular matrix. Endothelial cell-specific deletion of Itga9 (encoding integrin-alpha9) in mouse embryos results in the development of rudimentary valve leaflets… CONTINUE READING
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