Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion.

@article{Rezende2012IntegrinI,
  title={Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion.},
  author={Fl{\'a}via Figueiredo de Rezende and Augusto Martins Lima and Stephan Niland and Ilka Wittig and Heinrich Heide and Katrin Schroeder and Johannes A Eble},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 3},
  pages={521-31}
}
Upon adhesion to laminin-111, aortic smooth muscle cells initially form membrane protrusions with an average diameter of 2.9μm. We identified these protrusions also as subcellular areas of increased redox potential and protein oxidation by detecting cysteine sulfenic acid groups with dimedone. Hence, we termed these areas oxidative hot spots. They are spatially and temporally transient during an early stage of adhesion and depend on the activity of the H(2)O(2)-generating NADPH oxidase 4… CONTINUE READING