Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma.

@article{Zhou2014IntegrinC,
  title={Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma.},
  author={Bo Zhou and Katherine Nicole Gibson-Corley and Mary E. Herndon and Yihan Sun and Elisabeth A. Gustafson-Wagner and Melissa L.T. Teoh-Fitzgerald and F E Domann and M. David Henry and Christopher S. Stipp},
  journal={Molecular cancer research : MCR},
  year={2014},
  volume={12 1},
  pages={143-154}
}
UNLABELLED Significant evidence implicates α3β1 integrin in promoting breast cancer tumorigenesis and metastasis-associated cell behaviors in vitro and in vivo. However, the extent to which α3β1 is actually required for breast cancer metastasis remains to be determined. We used RNA interference to silence α3 integrin expression by approximately 70% in 4T1 murine mammary carcinoma cells, a model of aggressive, metastatic breast cancer. Loss of α3 integrin reduced adhesion, spreading, and… CONTINUE READING
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