Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2

@article{Inoue2003IntegrinM,
  title={Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2},
  author={Osamu Inoue and Katsue Suzuki-Inoue and W. Dean and Jon Frampton and Stephen P. Watson},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={160},
  pages={769 - 780}
}
Collagen plays a critical role in hemostasis by promoting adhesion and activation of platelets at sites of vessel injury. In the present model of platelet-collagen interaction, adhesion is mediated via the inside-out regulation of integrin alpha2beta1 and activation through the glycoprotein VI (GPVI)-Fc receptor (FcR) gamma-chain complex. The present study extends this model by demonstrating that engagement of alpha2beta1 by an integrin-specific sequence from within collagen or by collagen… CONTINUE READING

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Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2003
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