Integrin (α6β4) regulation of eIF-4E activity and VEGF translation

@article{Chung2002IntegrinR,
  title={Integrin (α6β4) regulation of eIF-4E activity and VEGF translation},
  author={Jun Min Chung and Robin E Bachelder and Elizabeth A. Lipscomb and Leslie M. Shaw and Arthur M Mercurio},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={158},
  pages={165 - 174}
}
We define a novel mechanism by which integrins regulate growth factor expression and the survival of carcinoma cells. Specifically, we demonstrate that the α6β4 integrin enhances vascular endothelial growth factor (VEGF) translation in breast carcinoma cells. The mechanism involves the ability of this integrin to stimulate the phosphorylation and inactivation of 4E-binding protein (4E-BP1), a translational repressor that inhibits the function of eukaryotic translation initiation factor 4E (eIF… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.

  • Molecular cancer research : MCR
  • 2010
VIEW 21 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Cellular survival: a play in three Akts.

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

eIF4E activity is regulated at multiple levels.

  • The international journal of biochemistry & cell biology
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL