Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.

  title={Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.},
  author={Yujin Hoshida and Sebastian M. B. Nijman and Masahiro Kobayashi and Jennifer A W Chan and Jean-Philippe Brunet and Derek Y. Chiang and Augusto Villanueva and Philippa Newell and Kenji Ikeda and Masaji Hashimoto and Goro Watanabe and Stacey Bolk Gabriel and Scott L Friedman and Hiromitsu Kumada and Josep M Llovet and Todd R. Golub},
  journal={Cancer research},
  volume={69 18},
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin… CONTINUE READING
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Oligonucleotide Common Molecular Subclasses of Hepatocellular Carcinoma

  • IizukaN, OkaM, Yamada-OkabeH
  • Cancer Res
  • 2009

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