Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma

  title={Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma},
  author={Naiara Costa Cinegaglia and S{\'o}nia Cristina da Silva Andrade and Tom{\'a}s Tok{\'a}r and Ma{\'i}sa Pinheiro and F{\'a}bio Eduardo Severino and Rog{\'e}rio Antonio de Oliveira and Erica Nishida Hasimoto and Daniele Cristina Cataneo and Antonio Jos{\'e} Maria Cataneo and J{\'u}lio Defaveri and Cristiano de P{\'a}dua Souza and M{\'a}rcia M. C. Marques and Robson Francisco Carvalho and Luiz Lehmann Coutinho and Jefferson Luiz Gross and S{\'i}lvia Regina Rogatto and Wan L. Lam and Igor Jurisica and Patricia Pintor dos Reis},
Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training (N = 24) and independent validation (N = 34) sets. Tissues were microdissected to obtain >90% tumor or normal lung cells, subjected to miRNA transcriptome sequencing and TaqMan quantitative PCR validation. We further integrated our data with published miRNA and mRNA expression datasets across 1,491 lung adenocarcinoma and 455 normal lung… CONTINUE READING
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