Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis.

@article{Chiricozzi2011IntegrativeRT,
  title={Integrative responses to IL-17 and TNF-$\alpha$ in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis.},
  author={A. Chiricozzi and E. Guttman-Yassky and M. Su{\'a}rez-Fari{\~n}as and K. Nograles and S. Tian and I. Cardinale and S. Chimenti and J. Krueger},
  journal={The Journal of investigative dermatology},
  year={2011},
  volume={131 3},
  pages={
          677-87
        }
}
Psoriasis is a complex inflammatory disease mediated by tumor necrosis factor (TNF)-α and cytokines secreted by specialized T-cell populations, e.g., IL-17, IL-22, and IFN-γ. The mechanisms by which innate and adaptive immune cytokines regulate inflammation in psoriasis are not completely understood. We sought to investigate the effects of TNF-α and IL-17 on keratinocyte (KC) gene profile, to identify genes that might be coregulated by these cytokines and determine how synergistically activated… Expand
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