Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast.

  title={Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast.},
  author={Daniel A. Skelly and Gennifer E Merrihew and Michael Riffle and Caitlin F. Connelly and Emily O. Kerr and Marnie Johansson and Daniel Jaschob and Beth J Graczyk and Nicholas Shulman and Jonathan Wakefield and Sara J. Cooper and Stanley Fields and William Stafford Noble and Eric G. D. Muller and Trisha N. Davis and Maitreya J. Dunham and Michael J. MacCoss and Joshua M. Akey},
  journal={Genome research},
  volume={23 9},
To better understand the quantitative characteristics and structure of phenotypic diversity, we measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 genetically diverse strains of Saccharomyces cerevisiae. More than 50% of all measured traits varied significantly across strains [false discovery rate (FDR) = 5%]. The structure of phenotypic correlations is complex, with 85% of all traits significantly correlated with at least one other phenotype (median = 6… CONTINUE READING
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