Integrative pathway genomics of lung function and airflow obstruction.

@article{Gharib2015IntegrativePG,
  title={Integrative pathway genomics of lung function and airflow obstruction.},
  author={Sina A. Gharib and Daan W. Loth and Mar{\'i}a Soler Artigas and Timothy P. Birkland and Jemma B. Wilk and Louise V. Wain and Jennifer A. Brody and Ma’en Obeidat and Dana B. Hancock and Wenbo Tang and Rajesh Rawal and H. Marike Boezen and Medea Imboden and Jennifer E. Huffman and Lies Lahousse and Alexessander Couto Alves and Ani W. Manichaikul and Jennie Hui and Alanna C. Morrison and Adaikalavan Ramasamy and Albert Vernon Smith and Vilmundur G. Gudnason and Ida Surakka and Veronique Vitart and David M. Evans and David P. Strachan and Ian J. Deary and Albert Hofman and Sven Gl{\"a}ser and James F. Wilson and Kari E. North and Jing Hua Zhao and Susan R. Heckbert and Deborah L. Jarvis and Nicole Probst-Hensch and Holger Schulz and R. Graham Barr and Marjo-Riitta Jarvelin and George T. O'Connor and Mika K{\"a}h{\"o}nen and Patricia A Cassano and Pirro G. Hysi and Jos{\'e}e Dupuis and Caroline Hayward and Bruce M. Psaty and Ian P. Hall and William C. Parks and Martin D. Tobin and Stephanie J. London},
  journal={Human molecular genetics},
  year={2015},
  volume={24 23},
  pages={
          6836-48
        }
}
Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loci, but explain only a modest portion of the phenotypic variability. We postulated that integrating pathway-based methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire of genes and processes influencing these traits. We performed two independent GWASs… 

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