Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.

@article{Hou2008IntegrativeGI,
  title={Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.},
  author={Qingsong Hou and Yong Wu and Heike Grabsch and Yansong Zhu and Siew Hong Leong and Kumaresan Ganesan and Debra Cross and Lay Keng Tan and Jiong Tao and Veena Gopalakrishnan and Bor Luen Tang and Oi Lian Kon and Patrick Tan},
  journal={Cancer research},
  year={2008},
  volume={68 12},
  pages={4623-30}
}
Recurrent genomic amplifications and deletions are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes and tumor suppressor genes within these regions can be challenging, as they often cover tens to hundreds of genes. Here, we combined high-resolution array-based comparative genomic hybridization (aCGH) with gene expression profiling to target genes within focal high-level amplifications in GC cell lines, and identified RAB23 as an amplified and… CONTINUE READING