Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.

@article{Roessler2012IntegrativeGI,
  title={Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.},
  author={Stephanie Roessler and Ezhou L. Long and Anuradha S. Budhu and Yidong Chen and Xuelian Zhao and Junfang Ji and Robert L Walker and Hu-Liang Jia and Qing-hai Ye and Lunxiu Qin and Zhao-You Tang and Ping He and Kent W. Hunter and Snorri Thorgeirsson and Paul S. Meltzer and Xin Wei Wang},
  journal={Gastroenterology},
  year={2012},
  volume={142 4},
  pages={
          957-966.e12
        }
}
BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression. METHODS We combined data from high-resolution, array-based comparative genomic hybridization and transcriptome analysis of HCC samples from 76 patients with hepatitis B virus infection with data on… 

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