Integrative genomic and transcriptomic analysis of leiomyosarcoma

  title={Integrative genomic and transcriptomic analysis of leiomyosarcoma},
  author={Priya Chudasama and Sadaf S Mughal and Mathijs A. Sanders and Daniel Huebschmann and Inn Chung and Katharina I. Deeg and S. Wong and Sophie Rabe and Mario Hlevnjak and Marc Zapatka and Aur{\'e}lie Ernst and Kortine Kleinheinz and Matthias Schlesner and Lina Sieverling and Barbara Klink and Evelin Schr{\"o}ck and Remco Michiel Hoogenboezem and Bernd Kasper and Christoph Heilig and Gerlinde Egerer and Stephan Wolf and Christof von Kalle and Roland Eils and Albrecht Stenzinger and Wilko Weichert and Hanno Glimm and Stefan Gr{\"o}schel and H. G. Kopp and Georg W Omlor and Burkhard Lehner and Sebastian B Bauer and Simon Schimmack and Alexis B. Ulrich and Gunhild Mechtersheimer and Karsten Rippe and Benedikt Brors and Barbara Hutter and Marcus Renner and Peter Hohenberger and Claudia Scholl and Stefan Fr{\"o}hling},
  booktitle={Nature Communications},
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknown. Here we show, using whole-exome and transcriptome sequencing, that LMS tumors are characterized by substantial mutational heterogeneity, near-universal inactivation of TP53 and RB1, widespread DNA copy number alterations including chromothripsis, and frequent whole-genome duplication… CONTINUE READING
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