Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

Abstract

PURPOSE Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large… (More)
DOI: 10.1200/JCO.2010.28.5148

Topics

3 Figures and Tables

Cite this paper

@article{Cho2011IntegrativeGA, title={Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.}, author={Y. Cho and Aviad Tsherniak and Pablo Tamayo and Sandro S. Santagata and Azra Hadi Ligon and Heidi Greulich and Rameen Berhoukim and Vladimir M. Amani and Liliana C. Goumnerova and Charles G. Eberhart and Ching C. Lau and James M. Olson and Richard J. Gilbertson and Amar Gajjar and Olivier Delattre and Marcel Kool and Keith L. Ligon and Matthew Meyerson and Jill P. Mesirov and Scott L. Pomeroy}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2011}, volume={29 11}, pages={1424-30} }