Integrative genome and transcriptome analyses reveal two distinct types of ring chromosome in soft tissue sarcomas.

Abstract

Gene amplification is a common phenomenon in malignant neoplasms of all types. One mechanism behind increased gene copy number is the formation of ring chromosomes. Such structures are mitotically unstable and during tumor progression they accumulate material from many different parts of the genome. Hence, their content varies considerably between and… (More)
DOI: 10.1093/hmg/ddt479

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