Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles

Abstract

t(8;21) is one of the most frequent chromosomal abnormalities observed in acute myeloid leukemia (AML). However, expression of AML1-ETO is not sufficient to induce transformation in vivo. Consistent with this observation, patients with this translocation harbor additional genetic abnormalities, suggesting a requirement for cooperating mutations. To better… (More)
DOI: 10.1084/jem.20150524

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