Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

  title={Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci},
  author={Clint L Miller and Milos Pjanic and Ting Wang and Trieu N Nguyen and Ariella Cohain and Jonathan D. Lee and Ljubica Perisic and Ulf Hedin and Ramendra K. Kundu and Deshna Majmudar and Juyong Brian Kim and Oliver Wang and Christer Betsholtz and Arno Ruusalepp and Oscar Franz{\'e}n and Themistocles L. Assimes and Stephen B. Montgomery and Eric E. Schadt and Johan Bj{\"o}rkegren and Thomas Quertermous},
  booktitle={Nature communications},
Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies have identified >150 loci associated with CAD and myocardial infarction susceptibility in humans. A majority of these variants reside in non-coding regions and are co-inherited with hundreds of candidate regulatory variants, presenting a challenge to elucidate their functions. Herein, we use integrative genomic… CONTINUE READING
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